X-rays size up protein structure at the “heart” of COVID-19 virus

Overlapping X-ray data of the SARS-CoV-2 main protease shows structural differences between the protein at room temperature (orange) and the cryogenically frozen structure (white). Graphic: Jill Hemman/ORNL, U.S. Dept. of Energy
A team of researchers at the Department of Energy’s Oak Ridge and Argonne national laboratories has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease, the enzyme that enables the virus to reproduce.
The X-ray measurements mark an important first step in the researchers’ ultimate goal of building a comprehensive 3D model of the enzymatic protein.
The ANS Young Members Group (YMG) is offering a series of live webinars—Spotlight on National Labs—to highlight the missions, key projects, and rising stars of the Department of Energy’s national laboratories. Recently it was Argonne National Laboratory’s turn to shine.