This work presents results of activation-aided determination of threshold reaction rates (RRs) in 92 samples of 209Bi, natPb, 197Au, 181Ta, 169Tm, natIn, 93Nb, 64Zn, 65Cu, 63Cu, 59Co, 19F, and 12C and in 121 samples of 27Al. All the samples are aligned with the proton beam axis inside and outside the demountable 92-cm-thick Pb target of 15-cm diameter assembled of 23 4-cm-thick discs. The samples are placed on 12 target disks to reproduce the long axis distribution of protons and neutrons. The target was exposed to an 800-MeV proton beam. The total number of protons onto the target was (6.0 ± 0.5) × 1015 . The RRs were determined by the direct gamma spectrometry techniques. In total, 1196 gamma spectra have been measured, and about 1500 RRs have been determined. The measured RRs were simulated by the MCNPX and SHIELD codes. A generally acceptable agreement of simulations with experimental data has been found.