Large-sized pressurized heavy water reactors (PHWRs) are neutronically loosely coupled and hence are prone to significant changes in flux shape during operation. As a result, they need a sophisticated regulation procedure based on an online flux mapping system (OFMS). During the reactor operation, neutron flux is continuously measured at certain predetermined in-core locations. The purpose of OFMS is to compute a detailed flux map at all points in the reactor, after every 2 min, by making use of the measured fluxes. The knowledge of detailed flux distribution is then used for an appropriate regulating action. The choice of computational method used by OFMS is of crucial importance because the method is expected to be both efficient and accurate and should work for a range of reactor configurations occurring during the operation. In this paper, three different methods, namely, flux synthesis, internal boundary condition, and combined least squares (CLSQ), are analyzed for their prospective use in the forthcoming 700-MW(electric) Indian PHWR. The CLSQ method is found to be most accurate, although it needs significant computation. A hybrid method that combines certain features of other methods is also studied and seems to give good accuracy with moderate computational effort.