The presence of impurities could affect the results observed in pure Ni. In particular, impurities could interact with self-interstitial atoms, which are highly mobile, effectively reducing their mobility. In this work we study the influence of the mobility of self-interstitials on He desorption. The nucleation of He-vacancy complexes is studied depending on the mobility of these self-interstitials in terms of He to vacancy content as well as concentration of these complexes.