TFTR performance has surpassed many of the previous tokamak records. This has been made possible by the use of tritium as fuel for DT plasma discharges. Stable operations of tritium systems provide for safe, routine DT operation of TFTR. In the preparation for DT operation, in the commissioning of the tritium systems and in the operation of the Nuclear Facility several key lessons have been learned. They include: the facility must take the lead in interpreting the applicable regulations and orders and then seek regulator approval; the use of ultra high vacuum technology in tritium system design and construction simplifies and enhances operations and maintenance; and central facility control under a single supervisory position is crucial to safely orchestrate operational and maintenance activities.